Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

نویسندگان

  • M D Houslay
  • A V Wallace
  • M E Cooper
  • N J Payne
  • S R Wilson
  • C M Heyworth
چکیده

Kasuga, M., Zick, Y., Blithe, D. L., Crettaz, M. & Kahn, C. R. (19826) Nature (London) 298, 667-669 Kasuga, M., Zick, Y., Blithe, D. L., Karlsson, F. A., Haring, H. U & Kahn, C. R. (1982~) J . Bwl. Chem. 257, 9891-9894 Kasuga, M., Fugita-Yamaguchi, Y., Blithe, D. L. & Kahn, C. R. (1983) Proc. Natl. Acad. Sci. U S A . 80, 2137-2141 Kowalski, A,, Gazzano, H., Fehlmann, M. & Van Obberghen, E. (1983) Biochem. Biophys. Res. Commun. 117, 885-893 Migliaccio, A., Lastoria, S., Montcharmont, B., Rotondi, A. & Auricchio, F. (1982) Biochem. Biophys. Res. Commun. 109, 10021010 Petruzelli, L. M., Ganguly, S., Smith, C. J., Cobb, M. H., Rubin, C. S. & Rosen, 0. M. (1982) Proc. Natl. Acad. Sci. U.S.A. 79, 6792-6796 Reynolds, F. H., Jr, Todaro, G. J., Fryling, C. & Stephenson, J. R. (1981) Nature (London) 292, 259-262 185-187 Roth, R. A. & Cassell, D. J. (1983) Science 219, 299-301 Shia, M. A. & Pilch, P. F. (1983) Biochemistry 22, 717-721 Teichberg, V. I., Sobel, A. & Changeux, J . P. (1977) Nature

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protein kinases and insulin action in fat cells.

the various guanine nucleotide regulatory proteins that have been fully characterized to date. It has been a matter of some contention as to whether insulin can exert an inhibitory effect upon adenylate cyclase activity. However, based upon our observations on the plasma-membrane cyclic AMP phosphodiesterase, it is apparent that such effects should only be observed at relatively high, but never...

متن کامل

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.

A method is described for preparing a plasma-membrane fraction from hepatocytes by a rapid, gentle, Percoll fractionation procedure. Cholera toxin elicited the ribosylation of a number of proteins in these membranes, including the components of the stimulatory guanine nucleotide regulatory protein, Ns. Insulin, however, inhibited the ability of cholera toxin to ribosylate a protein of Mr 25 000...

متن کامل

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

Hormones and most drugs initiate their biological actions by interacting with receptor macromolecules in or on cells. Of the receptors which are located in the plasma membranes of cells, many are coupled to specific effector molecules via intermediary coupling proteins. These are termed “G”-proteins, because they bind and hydrolyze the guanine nucleotide, GTP (1). Among the biological agents wh...

متن کامل

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

متن کامل

A Review of Mycoplasma in Laboratory Mice

Mycoplasma are small, cell-free bacteria enclosed by a membrane. These bacteria belong to the class of Mollicutes, the order of Mycoplasma tales, and the genus of Mycoplasma. There are more than 100 identified species of mycoplasma. The ratio of cytosine to guanine in its DNA is 23–40% and its genome size is 1350–600 kb. Mycoplasma require cholesterol to grow, and the temperature su...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 12 5  شماره 

صفحات  -

تاریخ انتشار 1984